Lanxess将产品组合与新的离子交换树脂延长，用于肝素生产和糖脱色

金宝搏官方网站特种化学品公司Lanxes188bet安卓客户端s正在消费者护理领域扩展其产品组合，以包括新的Lewatit pH 1074 HEP。除了发酵肉汤和糖的脱色，特别适用于肝素的纯化和中间储存。作为离子交换机的领先制造商之一，Lanxess打算使用这款创新产品来利用制药和生物处理行业的新客户，进一步加强其市场地位。

大型符合食品质量标准的大孔强的阴离子交换树脂基于交联的聚丙烯酸酯。它具有特殊的孔结构和树脂基质，其已被专门用于捕获高分子化合物。Lewatit pH 1074 HEP适用于衍生自生物质的产品的处理和纯化，因为它支持具有高分子量的可靠捕获和去除有机物质。这意味着可以纯化和处理液体糖糖浆或复杂的工艺溶液，例如发酵肉汤。

离子交换导致高肝素产量，活性和纯度

Sugar polymer heparin is used in medicine to prevent blood coagulation and venous thrombosis and is also applied as anticoagulant, for example, during heart surgery and dialysis. Heparin is typically purified with ion exchange resins, as this produces a higher yield, activity and purity of heparin and similar end products in comparison with precipitation processes for purification.

The methods used in the commercial production of pharmaceutical heparin are closely guarded operational secrets. All start with the collection of pig intestines from slaughterhouses, followed by the separation of the mucosal tissues. This is then broken down with enzymes in order to release heparin and polysaccharide derivatives.

Lewatit PH 1074 HEP helps extract the heparin from this complex mixture and then purify it. The ion exchanger can also be used to stabilize the heparin for transport and storage, which prevents the sugar polymer from breaking down.

The macroporous structure and special polymer matrix of the new Lewatit PH 1074 HEP help achieve optimum adsorption capacity and desorption properties. This is extremely advantageous in the recovery of high-molecular hydrophilic anionic organic substances, which, for example, are extracted from fermentation broths in the same way as heparin and other glycosaminoglycans (GAGs).

通过Lewatit pH 1074 HEP的成功分离和预纯化肝素，进行了进一步的纯化步骤，以生产患有药物质量标准的肝素。这包括去除残留肽和核苷酸，病毒和细菌内毒素，其可以通过漂白，酸洗和腐蚀性处理和用于病毒失活的氧化以及醇沉淀来实现。

Comprehensive service around the globe

业务单元的液体净化技术provides support during the validation process for the approval of Lewatit PH 1074 HEP in customer production processes with a comprehensive technical support package. The new ion exchanger is food-safe (EU Regulation No. 1935/2004), halal, kosher, non-GMO and free from allergens, heavy metals and TSE/BSE. More detailed information can be found athttps://lpt.lanxess.de/。